Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3

Abstract Background The problems associated with the poor water solubility of anticancer drugs are one most important challenges in achieving effective cancer therapy. present study was designed to evaluate effect scutellarein on human colon cells vitro by using a target α v β3 novel (Scu)-loaded niosome nanoparticle (β-CD-CL-Scu-cRGD). Results β-CD-CL-Scu-cRGD has diameter 140.2 nm and zeta potential − 11.3 mV constant physicochemical stability. MTT assay showed both Scu caused decrease cell proliferation viability LoVo, but better activity vitro. Colony formation flow cytometry that apoptosis. In vivo, animal experimental results can significantly inhibit tumor growth, bodyweight mice decreases during treatment its derivatives. could protein levels Ki67 αvβ3, thereby inhibiting growth. Conclusions Although further vivo studies necessary, our suggested be an outstanding carrier deliver for therapeutic approaches into cancer.